Moreover, Snail expression has been identified in non-epithelial cells, such as mesenchymal cells[15] and cancer-associated fibroblasts (CAFs)[11,16,17], that modify the tumor microenvironment by remodeling and rebuilding the extracellular matrix via matrix protease secretion and fiber deposition, thus creating an environment favorable to cancer growth and metastasis. Here, SNAI1 is linked to neoplasm.