Through the expression of master EMT transcription regulators, such as Snail, Slug, Twist family basic Helix-Loop-Helix (bHLH) transcription factor 1 (TWIST1), and Zinc finger E-box binding homeobox 1 and 2 (ZEB1/2), epithelial cancer cells not only decrease cell-cell adhesion through the inhibition of epithelial markers, like E-cadherin[31,32], they also increase expression of matrix metalloproteinases (MMPs)[39], increase chemotherapy resistance and cell survival[13], and contribute to the production of cancer stem-like cells (CSCs)[40]. Here, TWIST1 is linked to cancer.