In the early stages of EMT, Snail is known to inhibit the expression of E-cadherin (CDH1), tight junction protein 1 (TJP1 or ZO-1), and occludin (OCLN) in vitro[86]; however, its further mediation of ovarian cancer invasion and migration is complex, involving the regulation and modification of a variety of intracellular and extracellular factors [Table 2]. The gene discussed is OCLN; the disease is ovarian cancer.