EGFR and neoplasm: Although it has been reported that ARAP1 participates in regulating epidermal growth factor receptor (EGFR) endocytosis and ARAP1 is significantly lower in high-grade serous carcinoma (HGSC) tumor tissues of patients with early progression compared to those with late [22–25], the function of ARAP1 in tumorigenesis remains elusive and needs to further investigate.