On the other hand, those diagnosed as obstructive cholestasis (179) by histopathologic examination included 154 cases confirmed to be BA, 3 cases of choledochal cyst, 10 cases of PFIC-3, 7 cases as Alagille syndrome (paucity), and 5 metabolic causes including alpha-1 antitrypsin deficiency. The gene discussed is SERPINA1; the disease is Alagille syndrome.