For example, hypoxia has been shown to promote the release of lysyl oxidase (LOX), a HIF-1α target, derived from tumor cells, which reshapes the collagen proteins in the extracellular matrix (ECM) of the distant microenvironment, thereby facilitating the establishment of “pre-metastatic niches,” as demonstrated in mouse models of breast cancer [7]. This evidence concerns the gene LOX and breast carcinoma.