AKT1 and psoriasis: Prior studies also found that FOXO is mainly expressed in the cytoplasm of psoriatic keratinocytes, while is present in the nucleus of skin cells unaffected by psoriasis and normal skin cells.224 Hence, excessive activation of P-Akt may change the location of FOXO from the nucleus to the cytoplasm, resulting in reduced inhibition of cell proliferation and hyperproliferation of keratinocytes.