MTOR and psoriasis: Once completely activated, Akt acts as the core molecule and moves to the cytoplasm and nucleus to regulate the pathogenesis and progression of psoriasis via the downstream signaling pathway.217 As downstream factors of Akt, both forkhead box O (FOXO) and mammalian target of rapamycin (mTOR) regulate the growth, survival, and proliferation of keratinocytes.218