In addition, it is reported that through the interaction with the vascular addressin E-selectin, effector memory T (TEM) cells migrate to the skin and release IL-17, thereby participating in disease relapse.546 Lastly, it is worth mentioning that recent studies have revealed that skin epithelial stem cells (EpSCs) or basal keratinocytes with stemness can acquire long-term epigenetic memory during the course of psoriasis, which may play a potential role in the recurrence of skin inflammation in psoriasis.552 However, the above potential mechanisms still need to be verified in future works. This evidence concerns the gene IL17A and dermatitis.