Vorinostat, an HDAC inhibitor, is found to inhibit KC proliferation to induce their differentiation and apoptosis.338 Piperlongumine (PPL) can epigenetically inhibit histone-modifying enzymes, effectively enhancing the interactions of HDAC3 and p65 with IκB, indicating that PPL may be a potential medication in the treatment of psoriasis due to its suppression effect on cell proliferation and inflammation.339. This evidence concerns the gene HDAC3 and psoriasis.