GWAS have found that c-Rel, a gene encoding one of the members in the NF-κB family, is related to psoriasis susceptibility.169,170 Downregulation of c-Rel can inhibit the growth of keratinocytes by affecting their cell cycle progression.171 IL-23 is regarded as a direct target of c-Rel, and a decreasing level of c-Rel can also inhibit the production of IL-23.172 Thus, the susceptibility gene of c-Rel might be a promising target to treat and prevent psoriasis. This evidence concerns the gene NFKB1 and psoriasis.