Moreover, C1P was found to promote inflammation in the IMQ-induced psoriasis-like mouse model, and inhibition of C1P production via a ceramide kinase inhibitor could alleviate the psoriasis-like inflammation.295 In addition, using an untargeted lipidomics approach, our team found that substances involved in glycerophospholipid metabolism, such as lysophosphatidic acid (LPA), lysophosphatidylcholine (LysoPC), and phosphatidylinositol (PI), were significantly upregulated in the plasma of patients with psoriasis. This evidence concerns the gene CERK and psoriasis.