In addition, it is reported that through the interaction with the vascular addressin E-selectin, effector memory T (TEM) cells migrate to the skin and release IL-17, thereby participating in disease relapse.546 Lastly, it is worth mentioning that recent studies have revealed that skin epithelial stem cells (EpSCs) or basal keratinocytes with stemness can acquire long-term epigenetic memory during the course of psoriasis, which may play a potential role in the recurrence of skin inflammation in psoriasis.552 However, the above potential mechanisms still need to be verified in future works. The gene discussed is IL17A; the disease is psoriasis.