Subsequently, the complex regulates the NF-κB transcriptional signaling downstream of IL-17 signaling.258 In addition to acting on keratinocytes, PKM2 can also enhance the differentiation of Th17 cells, a crucial pathogenetic cell in psoriasis, by activating STAT3 or HIF-1α.259,260 All the above evidence suggests that PKM2 might be a potent therapeutic target for psoriasis. The gene discussed is PKM; the disease is psoriasis.