SLC2A1 and psoriasis: Recent studies found that pro-inflammatory cytokines can stimulate glucose uptake and glycolysis in human keratinocytes.251 Glucose uptake involves glucose transporters.252 Studies have suggested that the expression of glucose transporter-1 (GLUT-1) is upregulated in psoriatic lesions and is correlated with the severity of disease, indicating the important role of GLUT-1 in psoriasis.253,254 Further studies suggest that GLUT-1 is required for the proliferation and stress responses of keratinocytes.