It has been investigated that IL-17A and IL-17F can highly induce S100A8 and S100A9 expression and release.67 Moreover, IL-17 can promote keratinocyte stemness and then promote keratinocyte proliferation.68 Except for acting on keratinocytes, recent studies have revealed that IL-17A can also be involved in psoriasis via regulating other stromal cells, T cells, or monocytes. The gene discussed is IL17A; the disease is psoriasis.