The PI3K/Akt pathway has been regarded as an important mechanism in the occurrence and progression of psoriasis.213,214 A growing body of evidence has revealed that the activation of this pathway by external or internal stimulation can lead to epidermal hyperplasia, immune pathogenesis, angiogenesis, and other physiological or pathological processes related to psoriasis.215,216 Once activated by GFR tyrosine kinase, PI3K converts PIP2 into PIP3 on the plasma membrane. Here, RAPGEF5 is linked to psoriasis.