The activated STAT3 further increases the production of IκBζ, which is a key proinflammatory transcription factor required for cytokine synthesis and is induced in epithelial cells such as keratinocytes by IL-17 and polymorphisms in NFKBIZ (which encodes IκBζ and is recognized as one of the major susceptibility loci for psoriasis).238 Thus, treatment targeting the CDK4/6-EZH2 pathway is a promising strategy to tackle psoriasis. Here, NFKBIZ is linked to psoriasis.