STAT3 and psoriasis: Our further studies demonstrated that the upregulation of CD147 was stimulated by IL-22 via the activation of STAT3 and that CD147 knockdown could reduce the psoriatic changes, such as the production of cytokines, chemokines, and antimicrobial factors induced by IL-22.268 As discussed above, Th17 cells play a central role in psoriasis pathogenesis, and the energy required for the differentiation of Th17 cells comes from glycolysis.