IL17A and psoriasis: Among them, TRM cells are recognized as the major driver of psoriasis relapse.545 It is reported that effectors including CD69, integrins (CD49a, VLA-1, CD103, αvβ6, and αvβ8), aryl hydrocarbon receptor (AhR), CCR7, and the CCL27-CCR10 axis are related with the retention of TRM cells.546,547 A study using high-throughput screening on the T cell receptor (TCR) and immunostaining found that IL-17-producing resident αβT cells with psoriasis-specific antigen receptors were increased in psoriatic lesions and resolved psoriatic lesions, but not in the skin of healthy individuals.