Moreover, IL-6 can promote neutrophil migration by increasing the level of chemokines released by mononuclear cells/macrophages, such as IL-8 and MCP-1.153 Mature neutrophils also release pro-inflammatory cytokines such as IL-23 and IL-17 by responding to IL-6 through the membrane-bound IL-6R, which helps to establish a positive feedback loop for Th17 polarization.148 Based on these findings, IL-6 might serve as a pathogenic factor for psoriasis, and the blockade of IL-6 might bring benefits to patients with this disease. This evidence concerns the gene IL37 and psoriasis.