Moreover, topical application of GLUT inhibitor can also alleviate different forms of psoriasis in animal models, indicating that glucose transport might be a promising therapeutic target of psoriasis.255 Lately, our group found that HIF-1 α could promote glycolysis, which also plays a crucial role in psoriasis, by upregulating CD147/Basigin and GLUT1.256 Pyruvate kinase M2 (PKM2), a key rate-limiting enzyme of glycolysis, has a high level of expression in psoriasis. The gene discussed is SETD2; the disease is psoriasis.