INS and type 2 diabetes mellitus: Therefore, when initiating insulin therapy in hospitalized patients with type 2 diabetes (T2D) one-half of the total daily dose (TDD) was given as a basal dose (glargine or determir) once daily at bedtime, and the other half was given as a bolus (aspart, lispo, or glulisine) in equally divided doses before breakfast, lunch, and dinner regardless of TDD calculation based on body mass index (BMI) or random glucose level [2, 13, 14].