The survey by Dewi Guellec et al.8 found that patients with mild eosinophilia were less responsive to treatment.The role of eosinophils on risk factors may be related to the eosinophil cationic protein (ECP), mediators stored in granules throughout the cytoplasm synthesized by eosinophils33. The gene discussed is RNASE3; the disease is Increased total eosinophil count.