Furthermore, we used “gain of function” and “loss of function” assays in vitro to study the effect of RCC2 on PCa, and the results of the movement and invasion assays demonstrated that RCC2 facilitated cell propagation, movement, invasion, and EMT in two PCa cell lines DU145 and PC3, indicating the oncogenic role of RCC2 in PCa. The gene discussed is RCC2; the disease is posterior cortical atrophy.