Macrophages are recruited and educated by multiple factors in the TME, including colony-stimulating factor-1 (CSF1), GM-CSF, TGF-β, IL-1, IL-4, CCL2, CCL5, immune complexes, complement, histamine, tumor-derived non-coding RNAs [213, 227–230]. The gene discussed is TGFB1; the disease is neoplasm.