For instance, Xu et.al found that circRNA_0000392 promotes CRC progression through the miR-193a-5p/PIK3-AKT signaling pathway [26]; circPACRGL promotes progression of CRC via miR-142-3p/miR-506-3p [27]; CircALG1 promotes the progression and metastasis of CRC by binding to miR-342-5p [28]; CircHERC4 promotes tumor metastasis through absorbing miR-556-5p in CRC [29]. This evidence concerns the gene AKT1 and colorectal carcinoma.