TOP2A and hepatocellular carcinoma: To determine the prognostic value of the EZH2/miR-139-5p/TOP2A axis in HCC, we reanalyzed the prognostic data of HCC in the TCGA database and found that compared with patients with EZH2-low and TOP2A-low tumors, the prognosis of patients with EZH2-high and TOP2A-high tumors was worse (Fig. 7G).