Compared with adjacent normal tissues, the miR-139-5p level is lower in HCC tumor tissues; compared with low-EZH2 HCC, miR-139-5p expression was lower in high-EZH2 HCC; compared with low-TOP2A HCC, miR-139-5p expression was lower in high-TOP2A HCC (Fig. 7E). Here, TOP2A is linked to hepatocellular carcinoma.