Furthermore, the phospholipase Cε-dependent hydrolysis of PI(4)P at the Golgi is required for the DAG-mediated activation of nuclear PKD during cardiac hypertrophy (68) placing DGKε as a potential terminator of that signal concomitant with the resynthesis of the local pool of PA/PI(4)P. This evidence concerns the gene PRKD1 and cardiac hypertrophy.