Although high blood ANXA3 expression has been associated with different cancer types52,53 and interestingly, ANXA3 was included in a blood-based 7-gene biomarker panel for colorectal cancer discrimination56, this work appears to be the first one reporting high ANXA3 expression in whole blood of LC patients. The gene discussed is ANXA3; the disease is laryngotracheoesophageal cleft.