KEGG-enriched pathways analysed included pathways in cancer, Calcium signaling pathway, Neuroactive ligand‒receptor interaction, Proteoglycans in cancer, Ras Proteoglycans in cancer, Ras signaling pathway, Prolactin signaling pathway, MAPK signaling pathway, Phosphatidylinositol 3-kinase/Protein kinase B signaling pathway, PI3K-Akt signaling pathway, Epidermal growth factor receptor signaling pathway (EGFR tyrosine kinase inhibitor resistance), Estrogen signaling pathway (Estrogen signaling pathway), etc., as shown below Figs. 8 and 9. The gene discussed is EGFR; the disease is cancer.