Bloom DNA helicase (BLM) combines closely with DNA topoisomerase IIIα (Top3A), RecQ-mediated genome instability protein 1 (RMI1), and RecQ-mediated genome instability protein 2 (RMI2) to form a conserved Bloom syndrome (BS) complex, which is vital for maintaining genome stability [11]. This evidence concerns the gene RMI1 and Bloom syndrome.