Thus far, there is no effective treatment strategies for female infertility caused by TUBB8 variants, donor egg appears to be the most feasible treatment strategy for the females carrying pathogenic variants of TUBB8. Nevertheless, Jia et al. found that additional expression of wild-type TUBB8 cRNA in the mouse oocytes expressing mutant TUBB8 could rescue the embryonic development defects of resulting embryo and produce full-term offspring [33]. Here, TUBB8 is linked to female infertility.