Loss of Brn-3b also appears to be linked to structural and functional changes in the aortas and was strongly linked to hypertension and coronary artery disease either in Jensen.Disease pathway analysis or GWAS data showing that SNPs in Brn-3b genomic region (chromosome 4q31) were associated with increased risk of hypertension and CHD [40–42]. This evidence concerns the gene POU4F2 and coronary artery disorder.