Furthermore, the implications and effects of upregulation of genes that control circadian processes changes in Brn-3b KO aortas remain unknown but since disruption of the circadian rhythm is commonly associated with ageing and risk of vascular, cardiac and metabolic diseases [58, 98, 99], these mutants model could provide some interesting insight into the mechanisms linking such conditions. This evidence concerns the gene POU4F2 and metabolic disease.