Remodelling around Brn-3b KO coronary arteries pointed to potential roles for this TF in controlling vascular integrity and function(35) especially since published genome wide association studies (GWAS) data have identified SNPs associated with coronary heart disease (CHD), coronary artery diseases (CAD) and cerebrovascular accident (CVA) within the genomic region chromosome 4q (31.2), containing the Brn-3b genomic locus [40–45]. This evidence concerns the gene POU4F2 and coronary artery disorder.