Interestingly, genes affected by loss of Brn-3b were also implicated in human diseases since Jensen.disease pathway analysis (Table 1c) showed that the most significant pathways affected by genes upregulated in Brn-3b KO aortas were hypertension (169 genes; NES + 1.48) CAD (128 genes; NES + 1.53). The gene discussed is POU4F2; the disease is hypertensive disorder.