EZH2 and hepatocellular carcinoma: Our results indicated that some of the CpGs located in EMX1 gene bodies may represent functional elements under tumorigenesis circumstances, as they are associated with histone methylation modifications (such as H3K4 and H3K27), and histone (de)methylase enrichment (such as EZH2 and JARID) in HCC tissues and cell lines (Supplementary Fig. S6).