LEP and Insulin resistance: Reanalysis of a comprehensive dataset published by Wihelmi et al.21 that compared gene expression in islets from adult mice with obesity but not diabetic carrying a homozygous mutation in the leptin gene (Lepob, ob/ob, ND) to adult mice with obesity, hyperglycemia, and insulin resistance (New Zealand Obese, NZO, T2D) confirmed 1973 significant differential splicing events across 1,339 genes in diabetic conditions (Fig. S1Α).