To characterize the precise molecular functions of RBFOX2 that could be responsible for the Rbfox2-mut phenotype and were relevant to T2D, we focused on the intersection of differentially spliced genes across T2D islets, Rbfox2-mut islets, and Rbfox2-KD β cells that represented the top GO terms (Fig. 3F) and the transcripts that were both bound by RBFOX2 and whose splicing patterns changed in the presence or absence of RBFOX2 (Fig. S9A). The gene discussed is RBFOX2; the disease is type 2 diabetes mellitus.