S100A8 and gastric cancer: Research has shown that excessive salt consumption can facilitate Hp colonization, induce proliferation and pit cell hyperplasia, cause glandular atrophy, and thus enhance the carcinogenic effects of cagA ( +) Hp strains while promoting Hp-associated carcinogenesis [21, 22], the crucial role of high salt intake in gastric cancer was also indicated in many cohort studies [23, 24].