It was reported that TLR4 activated the NF-κB signaling pathway to induce the release of pro-inflammatory factors [31], and Resveratrol played protective effects against experimental periodontitis in mice via inhibiting the phosphorylation of NF-κB signaling molecules, including p65, p38MAPK, and STAT3 [32]. This evidence concerns the gene TLR4 and periodontitis.