Several factors, including older age [6], male gender [9], alpha-fetoprotein (AFP) [10, 11], aspartate aminotransferase (AST) [12], alanine transaminase (ALT) [12], gamma-glutamyl transferase (GGT) [13] and total bilirubin [13], were reported to be associated with the increased risk of HCC in patients with HCV or cirrhosis. This evidence concerns the gene AFP and Cirrhosis.