The administration of AAV9-KD-rMFN2 resulted in the satisfactory silencing of endogenous MFN2 and overexpression of exogenous MFN2 in the CNS of MitoCharc1 mice, in accordance with the data obtained by AAV9 gene therapy for other neurodegenerative diseases [41, 62, 64]. Here, MFN2 is linked to neurodegenerative disease.