MFN2 and Charcot-Marie-Tooth disease type 2A1: MFN2 is encoded by the nuclear MFN2 gene, whose mutations are mainly associated with the disease Charcot–Marie–Tooth type 2A (CMT2A; OMIM 609260), the most common subtype of axonal Charcot–Marie–Tooth (CMT) [1, 8–13], but also with severe neurological forms that involve the entire central nervous system (CNS) [3, 13, 14].