VEGFA and neoplasm: The adaptive UPR acts in tumors through a cell-autonomous mechanism contributing to the thriving and survival of the cells, and through cell non-autonomous mechanisms driving angiogenesis, for example, by increasing the master regulator of angiogenesis, vascular endothelial growth factor (VEGF), and the dysregulation of immune cells in the tumor microenvironment (TME) [7,8,32,42,62].