BCL2 and neoplasm: Pro-apoptotic members such as BAX promote apoptosis and are the most important pro-apoptotic members of the BCL-2-related gene encoding the BCL-2 family, while anti-apoptotic members such as BCL-2 hinder the mechanism of apoptotic cell death.20, 21, 22 Liu et al.23found that Ovatodiolide (Ova) inhibited tumor development, up-regulated the expression of BAX and down-regulated the expression of BCL-2, and increased the expression of E-cadherin.