Indeed, even if a positive correlation between [64Cu][Cu(ATSM)] and [18F]FMISO or HIF-1α has been shown in glioblastoma models [23, 24], other studies highlighted the failure of [64Cu][Cu(ATSM)] to correlate with hypoxic markers contrary to [18F]FMISO [25]. This evidence concerns the gene HIF1A and glioblastoma.