Compared with the si-NC group, A498 cells with lower TRIB3 expression exhibited much poorer cell viability at different time points (24 h, 48 h and 72 h post transfection) (Figure 9D), and the proliferation ability, colony formation potential and migration capacity were weakened in the si-TRIB3 group (Figure 9E–9I), which was consistent with the finding that TRIB3 positively affects cell proliferation and invasion in RCC cells, implying that TRIB3 is a tumor-promoting factor in KIRC. The gene discussed is TRIB3; the disease is renal cell carcinoma.