This may cause disruption in the microtubule network and impairment of axonal transport, eventually causing synaptic and neuronal degeneration.9 Tau inclusions have been found in nigral neurons by direct immunochemical studies of partially purified Lewy bodies and indirect immunohistochemical studies.10 In some studies, 50% of PD brains have tau inclusions.11 Furthermore, gait impairment in older people is associated with tau aggregation in substantia nigra.12 PD was not initially considered to be a typical tauopathy. This evidence concerns the gene MAPT and tauopathy.