The vital role of vitamin D and microbiota in immune responses, including autoimmunity, SOCS1, and SOCS3, have been reported to be involved in Vitamin D metabolism through the VDR-miRNA155-SOCS1 pathway, negatively regulating inflammation and disease pathogenesis [45,46,47,48,49,50]. The gene discussed is SOCS3; the disease is Autoimmunity.