Intratumoral electroporation of tavokinogene telseplasmid with PD-1 blockade increased immune cell infiltration and supported the IL-12/IFNγ feed-forward cycle, driving an intratumoral cross-presenting dendritic cell subpopulation with increased tumor infiltrating lymphocytes (TILs) and induced a higher than expected response rate in the patients with advanced melanoma, with a low frequency of checkpoint-positive cytotoxic lymphocytes [36]. The gene discussed is IFNG; the disease is melanoma.