Local intratumoral administration of SAR441000, a mixture of four mRNAs encoding IL12 single chain, IFNα2b, GM-CSF and IL15sushi, in immunocompetent mice, has shown successful antitumor immunity both in injected and noninjected tumors; in addition, combining the mRNAs with checkpoint inhibitors further enhanced antitumor responses, leading to tumor eradication and prolonged survival. This evidence concerns the gene CSF2 and neoplasm.