In preclinical models, a single intratumoral dose of mouse (m)IL12 mRNA stimulated IFNγ and CD8+ T-cell-dependent tumor regression in multiple syngeneic mouse models, and mice with a complete response showed memory immunity to rechallenge, in which antitumor activity was not linked to NK and NKT cells and was enhanced by anti-PD-L1 [90]. The gene discussed is IFNG; the disease is neoplasm.