The immunosuppressive cold tumor microenvironment lacks infiltrating antitumor T cells to eradicate tumor cells, but fills with MDSCs, M2-polarized macrophages and regulatory CD4+ T cells (Treg) as well as immunosuppressive cytokines like TGF-β, and is linked to the failure of systemic immunotherapy [8]. The gene discussed is TGFB1; the disease is neoplasm.