The combination of intratumoral IFNα-2b and IL-2 was tested in cystic glioblastoma, and the study found that dual cytokines could be safely injected into cystic glioblastoma without any evidence of side effects or an increase in surrounding tumoral edema, but 4 weeks of combined cytokine injection in ten glioblastoma patients had no effects on tumor progression [82]. Here, IFNA2 is linked to neoplasm.