Intratumoral delivery of recombinant attenuated Salmonella enterica serovar typhimurium vaccine significantly repressed Her-2/neu-expressing tumor growth by causing transformation of immunosuppressive MDSCs into TNF-α-secreting neutrophils and decreasing the generation of Treg cells, especially in the presence of tumor-specific CTLs [106]. This evidence concerns the gene TNF and neoplasm.