Additionally, Hoss et al. [103] observed that, as cancer cells express high levels of PSGL-1, they may easily bind to selectins (P-selectin, E-selectin, L-selectin) on the surface of blood cells to (i) evade immune system suppression, (ii) promote extravasation to constantly evade immune system control, and (iii) promote metastasis. This evidence concerns the gene SELPLG and cancer.