Furthermore, if we can show, in future studies, that prior to ART commencement there is a negative correlation between the levels of these markers of inflammation/translocation and PSGL-1 expression at different strata of CD4+ T-cell counts, then the role of PSGL-1 as a potential marker of inflammation and/or translocation during HIV infection may acquire important research value. The gene discussed is CD4; the disease is HIV infectious disease.