However, compared with the virus-infected group, the 6.25 μg/mL naringenin group, to which Cyclo (Phe-Pro) was added along with the virus infection, did not up-regulate the protein expression of RIG-I and MAVS, but instead significantly inhibited the protein expression of RIG-I and MAVS (Figure 7B,C). This evidence concerns the gene RIGI and viral infectious disease.