Our previously published study [9] reported that MIS-C among Indian children is characterized by elevated levels of cytokines (IFNγ, IL-2, TNFα, IL-1α, IFNα, IFNβ, IL-6, IL-15, IL-17A, GM-CSF, IL-10, and IL-33) and chemokines (CCL2, CCL19, CCL20 and CXCL10) at the systemic level as well as upon SARS-CoV-2 antigen stimulation [9,24], along with growth factors such as VEGF, acute phase proteins (CRP, α-2-Macroglobulin and serum amyloid P) and microbial translocation markers (LPS, sCD14, and LBP) [9,24] in the plasma of MIS-C children. This evidence concerns the gene IFNG and COVID-19–associated multisystem inflammatory syndrome in children.