Aside from CML and CDPK, Ca2+-transporters, such as Ca2+-ATPase and calcium-permeable stress-gated cation channel (CSC1), not only participate in Ca2+-dependent signal transduction pathways but also play a crucial role in maintaining ion homeostasis within cells [37]. Here, TMEM63C is linked to chronic myelogenous leukemia, BCR-ABL1 positive.