INS and type 1 diabetes mellitus: The baseline characteristics of the participants are as follows: mean (min–max) age 58 years (46–78), BMI 26 kg/m2 (21–30), duration of T1D 37 years (8–63), HbA1c 56 mmol/mol (42–66)/7.3% (6.0–8.2), and total daily insulin dose 43 IU (14–70).