Gestational DM, diagnosed with a 75 g Oral Glucose Tolerance Test (OGTT) (as per International Association of Diabetes and Pregnancy Study Group (IADPSG) guidelines) or with alternative tests for those women not tolerating the test, is managed by SBGM to check glucose levels and lifestyle changes (diet composition and physical activity) before considering the use of insulin and or metformin. The gene discussed is INS; the disease is diabetes mellitus.