Xu et al. [146] investigated the mechanism by which PTS affects Aβ1-42-induced cognitive impairment in mice and demonstrated that PTS effectively inhibits oxidative stress through the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, a key regulator of oxidative homeostasis closely associated with oxidative stress responses. The gene discussed is NFE2L2; the disease is Cognitive impairment.