SHC SH2 domain-binding protein 1 (SHCBP1) is an important connexin on the SH2 domain of the SHC protein, which is highly expressed in many malignant tumors; studies have shown that SHCBP1 promotes the development of cancer through multiple signaling pathways such as FGF, NF-κB, MAPK/ERK, PI3K/AKT and TGF-β1/Smad [15,16,17]. The gene discussed is TGFB1; the disease is cancer.