Wang et al. [40] predicted the main targets of retinoic acid in the treatment of lipopolysaccharide-induced cardiac insufficiency to be PPARA, ITGAM, VCAM-1, IGF-1, and IL-6 through network pharmacology, and found that RA can reduce lipopolysaccharide-induced cardiac insufficiency by regulating the PI3K-Akt signaling pathway and key genes. This evidence concerns the gene AKT1 and heart failure.