Since NLRP3 inflammasome has been reported to play a causal role in LPS-induced acute lung injury [43,44,45], it was speculated that the beneficial effects of tiliroside in vivo rely on its suppressive activity for the NLRP3 inflammasome, leading to the attenuation of inflammatory responses and the inhibition of lung injury in mice. Here, NLRP3 is linked to injury.