Paclitaxel inhibits regulatory cells (Tregs) and tumor-associated macrophages (TAMs), stimulates anti-tumor immunity and leads to the release of pro-apoptotic molecules such as Fas L, TNF-related apoptosis-inducing ligand (TRAIL) and cytokines such as TNF-α and IFN-γ [16,17]. Here, TNF is linked to neoplasm.