Some authors detected JTB as an overexpressed gene/protein in several malignant tissues and cancer cell lines, including liver cancer, prostate cancer, and BC, showing that this gene may suffer from unbalanced jumping translocation that leads to aberrant products, highlighting that the JTB downregulation/silencing increases cancer cell motility, anti-apoptosis, and promotes genomic instability and tumorigenesis. The gene discussed is JTB; the disease is liver cancer.