In this study, empty PLGA and PLGA(RGF) NPs were generated, and these 177Lu-PLGA(RGF)-CXCR4L NPs decreased cell viability and reduced the tumor size by inducing apoptosis of HCT116 colorectal cancer cells in a xenograft model via inhibiting Erk and Akt phosphorylation [180]. This evidence concerns the gene AKT1 and neoplasm.