The SDF1/CXCR4 axis, associated with cancer stem-like cells, is a target of cancer cells and can be overexpressed under pathological conditions; SDF1 is highly enriched in the bone marrow for CXCR4-positive hematopoietic stem cell (HSC) and also promotes tumor bone metastasis. This evidence concerns the gene CXCL12 and neoplasm.