Another larger interventional study included 101 obese participants with insulin resistance aged between 6–18 years and concluded that Bifidobacterium breve B632 and Bifidobacterium breve BR03 administered for 8 weeks leads to a significant improvement in insulin sensitivity, being also associated with lower levels of fasting insulin and alanine aminotransferase, but also decreased body mass index and waist circumference [114]. This evidence concerns the gene INS and Insulin resistance.