To address these challenges, we hypothesize that hybrid lipid nanoparticles made of biocompatible and biodegradable zein and conjugated to transferrin (whose receptors are overexpressed on cancer cells), able to entrap the hydrophobic anti-cancer drug docetaxel and carry plasmid DNA, would enhance the delivery of the therapeutic payloads to prostate cancer cells and increase their anti-proliferative efficacy and gene expression levels. The gene discussed is TF; the disease is prostate cancer.