To address this challenge, we hypothesize that the use of hybrid lipid nanoparticles composed of biocompatible and biodegradable zein and conjugated to transferrin (whose receptors are overexpressed on prostate cancer cells [7,8,9]) would be able to entrap the hydrophobic anti-cancer drug docetaxel and carry plasmid DNA. This evidence concerns the gene TF and Familial prostate cancer.