NPCe6/Pt treatment group showed excellent inhibition of tumor growth and even tumor regression in 4T1 tumors; DAMP release (CRT, HMGB1 ↑); DC maturation (CD80, CD86 ↑); T cell infiltration (CD4+ T cells, CD8+ T cells ↑);. The gene discussed is HMGB1; the disease is neoplasm.