FZD2 and amyotrophic lateral sclerosis: The expression levels of Wnt3, Wnt4, FZD2, FZD8, Wnt2b, Wnt5a, FZD3, LRP5, and sFRP3 are elevated in the human spinal cord tissue of patients diagnosed with ALS, wherein there is an increase in the population of astrocytes expressing the FZD2 receptor in the transitional region between the grey and white matter at the ventral horn.