Colony-stimulating factor 1 receptor (CSF1R)-related adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) has a primarily intrinsic microglial defect, and allogeneic HSC transplantation has been performed and shows promising results regarding the stabilization of disease progression including cognitive decline and motor function [130]. Here, CSF1R is linked to Mental deterioration.