MYOM2 and Miyoshi myopathy: Multiple myeloma (MM) is a B-cell malignancy derived from an expansion of clonal plasma cells in the bone marrow, which produce monoclonal immunoglobulins (M-protein) that could settle down into vital organs, causing their progressive dysfunction, with the typical CRAB clinical MM manifestations such as osteolytic bone disease, anemia, or renal failure [1].