The engagement of CD3 is the major proliferation signal, even if additional indirect mechanisms are promoted by the cytokines storm and production of cytolytic molecules, like perforin and granzymes (granzyme B, IFN-γ, IL2, IL6, IL8, IL10, and TNF-α), from T cells, resulting in MM cell lysis. The gene discussed is IL6; the disease is Miyoshi myopathy.