While there is a scarcity in the literature linking these variables (CD39/ectonucleotidases x TUR and/or prostatectomy), it is known that the CD39/CD73 pathway can be influenced by a range of physiopathological events beyond cancer, including infections, autoimmune diseases, ischemia, infarcts, and more [11]. This evidence concerns the gene ENTPD1 and autoimmune disease.